Views
5 years ago

108 - E Carranza Vélez - Febrero 2018

  • Text
  • Neuroplasticidad
  • Esquizofrenia
  • Colesterol
  • Tspo
  • Protein
  • Dehidroepiandrosterona
  • Pregnenolina
  • Allopregnenolona
  • Velez
  • Receptores
  • Gaba
  • Receptor
  • Pregnenolona
  • Neuronas
  • Neuronal
  • Neuroesteroides
  • Esteroides
  • Subunidades
  • Nmda
Neuroesteroides: modulación de receptores y blancos farmacológicos. Foco en esquizofrenia. Parte 1 - Dra. Estela Carranza Vélez

Dra. Estela

Dra. Estela Carranza Vélez Bibliografía • Alvano, S y Bauleo, A (Mediciencia). (2004). Avatares de la clínica. Un proyecto de complementariedad entre neurociencias y psicoanálisis. Buenos Aires. Grupo editor MEDIciencia • Baulieu, E.E., (1981). Steroid hormones in the brain: several mechanisms? In: Fuxe, K., Gustafsson, J.A., Wetterberg, L. (Eds.), Steroid Hormone Regulation of the Brain. Pergamon Press, Oxford. • Baulieu, E.E., (1997). Neurosteroids: of the nervous system, by the nervous system, for the nervous system. Recent Prog. Horm. Res. 52, 1–32. • Belelli D, Lambert JJ. (2005) Neurosteroids: endogenous regulators of the GABA(A) receptor. Nat Rev Neurosci; 6: 565-75. • Bianchi, J.J. Hagan, C.A. Heidbreder. (2005) Neuronal plasticity, stress and depression: involvement of the cytoskeletal microtubular system? Drug Targets CNS Neurol. Disord. 4 597–611. • Bondolfi Olga. (2014) Receptores NMDA: Plasticidad sináptica y supervivencia neuronal, psicofarmacología 2014; 85: 21-30. • Brown, A.R., Herd, M.B., Belelli, D., Lambert, J.J., (2015). Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones. J. Physiol. 593, 267e284. • Birkenhager-Gillesse EG, Derksen J, Lagaay AM. (1994) Dehydroepiandrosterone sulphate (DHEAS) in the oldest old, aged 85 and over. Ann N Y Acad Sci; 719: 543-52. • Brown A.R., S J. Mitchell, D. R. Peden, Murray B. Herd, M. Seifi, J. D. Swinny, D. Belelli, J.J. Lambert. (2016). “During posnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons”. J. Neuropharm 103, 163-1. • Caruso D, Abbiati F, Giatti S, Romano S, Fusco L, Cavaletti G, Melcangi RC (2015). Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids incerebrospinal fluid and plasma. J Steroid Biochem Mol Biol; 146:74–79. • Costa E, Guidotti A. (1996) Benzodiazepines on trial: a research strategy for their rehabilitation. TIPS; 17: 192–200. • Charalampopoulos I, Alexaki VI, Tsatsanis C, Minas V, Dermitzaki E, Lasaridis I, Vardouli L, Stournaras C, Margioris AN, Castanas E, Gravanis A. (2006). Neurosteroids as endogenous inhibitors of neuronal cell apoptosis in aging. Ann N Y Acad Sci 1088:139–152. • Deidda, G., Bozarth, I.F., Cancedda, L., (2014). Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives. Front. Cell Neurosci. 8, 119. • Farrant, M. & Nusser, Z. (2005). Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors. Nature Rev.Neurosci. 6, 215–229. • Fontaine-Lenoir, B. Chambraud, A. Fellous, S. David, Y. Duchossoy, E.E. Baulieu, P. Robel (2006). Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor, Proc. Natl. Acad. Sci. U. S. A. 103: 4711–4716. • Fritschy, J.M., Panzanelli, P., (2014). GABAA receptors and plasticity of inhibitory neurotransmission in the central nervous system. Eur. J. Neurosci. 39, 1845e1865. • Fuller R, Nopoulos P, Arndt S, O'Leary D, Ho BC, Andreasen NC. (2002) Longitudinal assessment of premorbid cognitive functioning in patients with schizophrenia through examination of standardized scholastic test performance. Am J Psychiatry. Jul; 159 (7):1183-9. • Fuxe K, Gustafsson JA, Weterberg L. (1981) Steroideds hormone regulationof the brain. Oxford: Pergamon Press; p. 3-14. • Harney, S. C., Frenguelli, B. G. & Lambert, J. J. (2003). Phosphorylation influences neurosteroid modulation of synaptic GABAA receptors in rat CA1 and dentate gyrus neurones. Neuropharmacology 45, 873–883. • Harrison, N. L. & Simmonds, M. A. (1984). Modulation of the GABA receptor complex by a steroid anaesthetic Brain Res. 323, 287–292 (1984). • Hönig Guillermo Joaquín. (2009) Alteraciones de la Corteza Prefronatl en esquizofrenia (Tercera parte), psicofarmacología; 54: 25-34. • Hosie, A. M., Wilkins, M. E., da Silva, H. M. A., & Smart, T. G. (2006). Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites. Nature 444, 486-489. • Kapur, S., Seeman, P. (2001). Does fast dissociation from the dopamine D (2) receptor explain the action of atypical antipsychotics?: a new hypothesis. Am. J. Psychiatry 158, 360–369. • Keefe RSE, Buchanan RW, Marder SR, Schooler NR, Dugar A, Zivkov M. (2011) Clinical trials of potential cognitiveenhancing drugs in schizophrenia: what have we learned so far? Schizophr Bull; 39 (2): 417-35. • Kostakis E, Smith C, Jang MK, Martin SC, Richards KG, Russek SJ. (2013). The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl-D-aspartate receptors to the cell surface via a noncanonical G-protein and Ca2+-dependent mechanism. Mol Pharmacol; 84:26. • Krystal y Moghaddam (2011). Contributions of glutamate and GABA system to the neurobiology and treatment of schizophrenia. En Schizophrenia, 3rd edition. Edited by Daniel R. Weinberger and Paul J Harrison. Blackwell Publishing Ltd. • Lambert, J. J. et al.,. Neurosteroid modulation of GABAA receptors (2003). Prog. Neurobiol. 71, 67–80. • Lisman JE, Coyle, Robert. Green, Daniel C. Javitt Francine M. Benes, Stephan Heckers, and Anthony A. Grace. (2008). “Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia” Trends Neurosci. May; 31(5): 234–242. • Lisman JE, Grace AA (2005). The hippocampal-VTA loop: controlling the entry of information into long term memory. Neuron; 46: 703–713. • LoTurco JJ, Owens DF. (1995) Health MJ. GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis. Neuron; 15: 1287-98. • Maguire J, Mody I. (2008) GABAAR “plasticity during pregnancy: relevance to postpartum depression”. Neuron; 59: 207–213. • Majewska, M. D. Schwartz, R. D. (1987). Pregnenolonesulfate: an endogenous antagonist of the gamma-aminobutyric acid receptor complex in brain? Brain Res 404, 355– 360. • Marx CE, Stevens RD, Shampine LJ, Uzunova V, Trost WT, Butterfield MI, Massing MW, Hamer RM, Morrow AL, Lieberman JA (2006) Neuroactive steroids are altered in schizophrenia and bipolar disorder: relevance to pathophysiology and therapeutics. Neuropsychopharmacology 31:1249–1263. • Maurice, C. Grégoire, J. Espallergues. (2006). Neuroactive steroids actions at the neuromodulatory sigma1 (s1) receptor: biochemical and physiological evidences consequences in neuroprotection, Pharmacol. Biochem. Behav. 84: 581–597. • McEwen, B. S., Coirini, H. & Schumacher. (1990) M. Steroid effectson neuronal activity: when is the genome involved? CibaFound. Symp. 153, 3–12. • McEwen, B. S. (1991). Non-genomic and genomic effects of steroids on neural activity. Trends Pharmacol. Sci. 12,141–147. • Mayo W, Dellu F, Robel P, Cherkaoui J, Le Moal M, Baulieu EE, Simon H (1993) Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat. Brain Res 607:324–328. • Mayo W, George O, Darbra S, Bouyer JJ, Vallee M, Darnaudery M. (2003) Individual differences in cognitive aging: implication of pregnenolone sulfate. Prog Neurobiol; 71: 43-8. • Mayo W, Lemaire V, Malaterre J, Rodriguez JJ, Cayre M, Stewart MG, Kharouby M, Rougon G, Le Moal M, Piazza PV, Abrous DN (2005) Pregnenolone sulfate enhances neurogenesis and PSA-NCAM in young and aged hippocampus. Neurobiol Aging 26:103–114. • Morales AJ, Nolan JJ, Nelson JC, Yen SS. (1994). Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab 1994; 78: 1360-7. • Murakami, A. Fellous, E.E. Baulieu, P. Robel. (2000) Pregnenolone binds to microtubule-associated protein 2 and stimulates microtubule assembly, Proc. Natl. Acad. Sci. U. S. A. 97 3579–3784. • Papaleo Pedro Ricardo. (2011). Alteración de la memoria de trabajo en la esquizofrenia, psicofarmacología; 70: 19-28. • Phan KL, Taylor SF, Welsh RC, Ho SH, Britton JC, Liberzon I (2004). Neural correlates of individual ratings of emotional salience: a trial-related fMRI study. NeuroImage 21: 768– 780. • Patchev VK, Shoaib M, Holsboer F, Almeida OF (1994) The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus. Neuroscience 62:265–271. • Porcu P, Barron AM, Frye CA, Walf AA, Yang SY, He XY, Morrow AL, Panzica GC, Melcangi RC. (2016). Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research. J Neuroendocrinol. Feb; 28(2):12351. • Reddy DS, Kaur G, Kulkarni SK. (1998). Sigma (sigma1) receptor mediated anti-depressant-like effects of neurosteroids in the Porsolt forced swim test. Neuroreport 9: 3069– 3073. • Represa A, Ben-Ari Y. (2005). Trophic actions of GABA on neuronal development. Trends Neurosci; 28: 278-83. • Ritsner MS, Gibel A, Shleifer T, Boguslavsky I, Zayed A, Maayan R, Weizman A, Lerner V (2010) Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, doubleblind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 71:1351–1362. • Shampine LJ (2009). Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 34:1885–1903. • Schule, C., di Michele, F., Baghai, T., Romeo, E., Bernardi, G., Zwanzger, P., Padberg, F., Pasini, A., Rupprecht, R., (2003). Influence of sleep deprivation on neuroactive steroids in major depression. Neuropsychopharmacology 28, 577–581. • Schmidt PJ, Daly RC, Bloch M, Smith MJ, Danaceau MA St, Clair LS. (2005). Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression. Arch Gen Psychiatry 62: 154–162. • Schule C, Nothdurfter C, Rupprecht R. (2014) “The role of allopregnanolone in depression and anxiety”. Prog Neurobiol; 113: 79–87. • Schumacher M, Weill-Engerer S, Liere P, Robert F, Franklin RJ, García-Segura LM, (2003). Steroid hormones and neurosteroids in normaland pathological aging of the nervous system. Prog Neurobiol; 71: 3-29. • Schumacher M, Mattern C, Ghoumari A, Oudinet JP, Liere P, Labombarda F, Sitruk-Ware R, De Nicola AF, Guennoun R. (2014). Revisiting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors. Prog Neurobiol. Feb; 113:6-39. • Sieghart, W., &Sperk, G. (2002). Subunit composition, distribution and function of GABAA receptor subtypes. Curr Top Med Chem 2, 795–816. • Smith C, Gibbs T, Farb H. (2014). “Pregnenolone sulfate as a modulator of synaptic plasticity” Psychopharmacology (Berl). September; 231(17): 3537–3556. • Sripada RK, Marx CE, King AP, Rajaram N, Garfinkel SN, Abelson JL, Liberzon I. DHEA enhances emotion regulation neurocircuits and modulates memory for emotional stimuli. Neuropsychopharmacology. 2013 Aug; 38(9):1798-807. • Stell, B. M. et al.,. Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by d subunit-containing GABAA receptors. Proc. Natl Acad. Sci. USA 100, 14439–14444 (2003). • Svízenská, P. Dubovy, A. Sulcová (2008). Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures: a short review, Pharmacol. Biochem. Behav. 90: 501–511. • Tu LN, Morohaku K, Manna PR, Pelton SH, Butler WR, Stocco DM, Selvaraj V. (2014). Peripheral benzodiazepine receptor/translocator protein globalknock-out mice are viable with no effects on steroid hormone biosynthesis. J Biol Chem; 289: 27444–27454. • Vicini, S., Losi, G. & Homanics, G. E. GABAA receptor d subunit deletion prevents neurosteroid modulation of inhibitory synaptic currents in cerebellar neurons. Neuropharmacology 2002; 43, 646–650. • Vallée M, Shen W, Heinrichs SC, Zorumski CF, Covey DF, Koob GF, Purdy RH (2001) Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats. Eur J Neurosci 14:2003–2010. • Vallée M. (2015) Neurosterids and potential therapeutics: Focus on pregnenolone. J. Steroid Biochem. Mol.Biol. • Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ. (2004). Epigenetic programming by maternal behavior. Nat Neurosci; 7(8):847-54. • Wienberger, DR and Harrison, PJ: “Schizophrenia”. Third Edition. Edited by Daniel R. Weinberger and Paul J Harrison © 2011 Blackwell Publishing Ltd. • Zieher L. M, Brio M. C. (2009) “Actualización en la patofisiología de la esquizofrenia desde la perspectiva de las neurociencias de sistemas”. Psicofarmacología; 56: 9-16. Editorial Sciens. • Zieher L. M, Brio M.C. y col. (2009). “Tratado de Psicofarmacología y Neurociencias. Volumen I. Esquizofrenia y otras psicosis. Neurobiología y terapéuticas”. Editorial Sciens. 18 // EDITORIAL SCIENS

Biblioteca

Av. García del Río 2585 Piso 12 A - C.A.B.A
+54 11 2092 1646 | info@sciens.com.ar

Editorial Sciens, Todos los Derechos Reservados 2015