Views
4 years ago

D Sotelo, HE Gnocchi, AP Sáenz - Octubre 2019

  • Text
  • Sotelo
  • Octubre
  • Psiquiatria
  • Schizophr
  • Riesgo
  • Signos
  • Schizophrenia
  • Prevalencia
  • Psychiatry
  • Enfermedad
  • Esquizofrenia
  • Pacientes
  • Neurological
Una revisión sobre los Signos Neurológicos Blandos en esquizofrenia

su sentido. Los SNB

su sentido. Los SNB pueden representar una línea de estudio que persigue un cambio conceptual en el enfoque de una compleja enfermedad, con el objetivo de arribar menos tardíamente a su diagnóstico y aspirar, de ese modo, a obtener resultados más alentadores. Finalmente, el estudio de estos síntomas neurológicos representa un desafío para los psiquiatras. Su presencia y su valor están bien establecidos. “Que su significado aún sea incierto no refleja la irrealidad de los hallazgos, sino limitaciones en nuestro conocimiento” (17). Referencias bibliográficas 1. Thaker G, Carpenter W. Advances in schizophrenia. Nature Medicine 2001, Vol 7, Num 6 667-671. 2. Asociación Americana de Psiquiatría. Manual Diagnóstico y Estadístico de los trastornos mentales (DSM-5), 5° Ed. Arlington, VA, Asociación Americana de Psiquiatría, 2014. 3. Sotelo D. Diskinesias espontáneas en pacientes esquizofrénicos. Psicofarmacología 34, 2005, 23-28. 4. Walther S, Strik W. Motor symptoms and schizophrenia. Neuropsychobiology. 2012;66(2):77-92. 5. Compton M, Fantes F, Ramsay Wan C, Johnson S, Walker E. Abnormal movements in first-episode, non affective psychosis: dyskinesias, stereotypies, and catatonic-like signs Psychiatry Res. 2015 Mar 30; 226(1): 192–197. 6. Burton BK, Hjorthøj C, Jepsen JR, Thorup A, Nordentoft M, Plessen KJ. Research Review: Do motor deficits during development represent an endophenotype for schizophrenia? A meta-analysis. J Child Psychol Psychiatry. 2016 Apr;57(4):446-56. 7. Pappa S, Dazzan P. Spontaneous movement disorders in antipsychotic-naïve patients with first-episode psychoses: a systematic review. Psychol Med. 2009 Jul;39(7):1065-76. 8. Bender L, Fink N, Green M. Childhood schizophrenia: Clinical study of 100 schizophrenic children. Am J Orthopsychiatry 1947;17:40‐56. 9. Tamminga CA. Schizophrenia and other psychotic disorders. In: Sadock BJ, Sadock VA, Ruiz P, editors. Kaplan and Sadock’s Comprehensive Textbook of Psychiatry. 9th ed. Philadelphia: Lippincott Williams & Wilkins; 2009. p. 1432‐628 10. Chan RC, Xu T, Heinrichs RW, Yu Y, Wang Y. Neurological soft signs in schizophrenia: a meta-analysis. Schizophr Bull. 2010 Nov;36(6):1089- 104. 10.1093. 11. Shaffer D, O’Connor PA, Shafer SQ, Prupis S. Neurological soft signs: Their origins and significance for behaviour. In: Rutter M, editor. Developmental Neuropsychiatry. New York: Guildford Press; 1983. p. 145‐63. 12. Woods BT, Yurgelun‐Todd D, Kinney DK. Relationship of neurological abnormalities in schizophrenics to family psychopathology. Biol Psychiatry 1987;22:325‐31. 13. Peralta V, Moreno-Izco L, Sanchez Torres A, García de Jalón E, Campos M, y Cuesta M. Characterization of the Deficit Syndrome in Dug-Naive Schizophrenia Patients: The Role of Spontaneous Movement Disorders and Neurological Soft Signs Schizophr Bull. 2014 Jan; 40(1): 214–224. 14. Kraepelin E. La Demencia Precoz. 1º Edición en castellano. Buenos Aires. Polemos. 1996. 51-53. 15. Whitty PF, Owoeye O, Waddington JL (2009). Neurological signs and involuntary movements in schizophrenia: intrinsic to and informative on systems pathobiology. Schizophr Bull 35:415–424. 16. Tsuang MT, Faraone SV (1999). The concept of target features in schizophrenia research. Acta Psychiatr Scand Suppl 395:2–11. 17. Heinrichs DW, Buchanan RW. Significance and meaning of neurological signs in schizophrenia. Am J Psychiat 1988;145(1):11–1. 18. Gupta S, Andreasen NC, Arndt S, et al. Neurological soft signs in neuroleptic-naive and neuroleptic-treated schizophrenic patients and in normal comparison subjects. Am J Psychiatry;152:191–196. 1995. 19. Browne S, Clarke M, Gervin M, Lane A, Waddington JL, Larkin C, et al. Determinants of neurological dysfunction in first episode schizophrenia. Psychol Med 2000;30:1433‐4. 20. Devabhaktuni S, Saldanha D, Chaudhury S, Sahu S. Neurological Soft Signs in Positive and Negative Subtypes of Schizophrenia Medical Journal of Dr. D.Y. Patil Vidyapeeth 2019. 227 - 232. 21. The Scottish First Episode Schizophrenia Study. I. Patient identification and categorisation. The Scottish Schizophrenia Research Group. Br J Psychiatry 1987;150:331‐3 22 Manschreck TC, Maher BA, Rucklos ME, Vereen DR. Disturbed voluntary motor activity in schizophrenic disorder. Psychol Med 1982;12:73‐84. 23. Bombin I, Arango C, Buchanan R, Significance and Meaning of Neurological Signs in Schizophrenia: Two Decades Later. Schizophrenia Bulletin vol. 31 no. 4 pp. 962–977, 2005 doi:10.1093/schbul/sbi028. 24. Buchanan RW, Heinrichs DW. The neurological evaluation scale (NES): A structured instrument for the assessment of neurological signs in schizophrenia. Psychiatry Res 1989;27:335‐50. 25. Torrey EF. Neurological abnormalities in schizophrenic patients. Biol Psychiatry. 1980 Jun;15(3):381-8. 26. Chan RCK, Xu T, Heinrichs RW, Yu Y, Wang Y (2010) Neurological soft signs in schizophrenia: a meta analysis. Schizophr Bull 36:1089–1104. 26. Albayrak Y, Akyol ES, Beyazyüz M, Baykal S, Kuloglu M (2015) Neurological soft signs might be endophenotype candidates for patients with deficit syndrome schizophrenia. Neuropsychiatric Disease and Treatment 2015:11 2825–2831. 27. Keefe R, Eesley C. Deficits Neurocognitivos en Tratado de esquizofrenia, Liberman J, Scott Stroup, T, Perkins, D, Ars Medica 2008 243-258. 28. Bonilha L, Molnar C, Horner MD, Anderson B, Forster L, George MS, Nahas Z. Neurocognitive deficits and prefrontal cortical atrophy in patients with schizophrenia. Schizophr Res. 2008 Apr;101(1-3):142-51. 29. Quitkin F, Rifkin A, Klein DF (1976). Neurological soft signs in schizophrenic and character disorders. Arch Gen Psychiatry 33:845–853. 30. Sanders RD, Keshavan MS, Schooler NR (1994) Neurological examination abnormalities in neuroleptic-naïve patients with first break schizophrenia: preliminary results. Am J Psychiatry 151:1231–1233. 31. Venkatasubramanian G, Latha V, Gangadhar BN, Janakiramaiah N, Subbakrishna DK, Jayakumar PN, Keshavan MS (2003) Neurological soft signs in never-treated schizophrenia. Acta Psychiatr Scand 108:144–146. 32. Chan RCK, Xie W, Geng FL, Wang Y, Lui SSY, Wang CY, Yu X, Cheung EFC, Rosenthal R (2016). Clinical utility and lifespan profiling of neurological 4 // EDITORIAL SCIENS

Psiquiatría | Octubre 2019 soft signs in schizophrenia spectrum disorders. Schizophr Bull 42:560–570. 33. Madsen AL, Vorstrup S, Rubin P, Larsen JK, Hemmingsen R. Neurological abnormalities in schizophrenic patients: a prospective follow-up study 5 years after first admission..Acta Psychiatr Scand. 1999 Aug;100(2):119-25. 34. Chen EY, Hui CL, Chan RC, Dunn EL, Miao MY, Yeung WS, Wong CK, Chan WF, Tang WN. A 3-year prospective study of neurological soft signs in first- episode schizophrenia. Schizophr Res. 2005 Jun 1;75(1):45-54. 35. Bachmann S, Bottmer C, Schröder J. Neurological soft signs in first-episode schizophrenia: a follow-up study. Am J Psychiatry. 2005 Dec;162(12):2337- 43 )r Res. 2005 Jun 1;75(1):45-54. 36. Bachmann S, Degen C, Geider FJ and Schröder J (2014). Neurological soft signs in the clinical course of schizophrenia: results of a meta-analysis. Front. Psychiatry 5:185. doi: 10.3389/fpsyt.2014.00185). 37. Chan R, Cui H, Chu M, Zhang T, Wang T, Li Z, et al. Neurological soft signs precede the onset of schizophrenia: a study of individuals with schizotypy, ultra-high-risk individuals, and first-onset schizophrenia Eur Arch Psychiatry Clin Neurosci 2017 DOI 10.1007/s00406-017-0828-4. 38. Mayoral M, Bombin I, Zabala A, Robles O, Moreno D, Parellada M, Ruiz-Sancho A, Arango C (2008). Neurological soft signs in adolescents with first episode psychosis: two-year follow up. Psychiatry Res 161:344–348. 39. Emsley R, Chiliza B, Asmal L, Kilian S, Riaan Olivier M, Phahladira et al. Neurological soft signs in first-episode schizophrenia: State- and trait-related relationships to psychopathology, cognition and antipsychotic medication effects. Schizophr Res. 2017 Oct;188:144-150. 40. Yung A. Treatment of people at ultra-high risk for psychosis World Psychiatry. 2017 Jun; 16(2): 207–208. 41. Yung A, McGorry PD, McFarlane CA et al. Schizophr Bull 1996;22:283-303.) la prevalencia de los SNB es significativamente más alta que en los controles. 42. Velakoulis D, Yung A, Brewer W, McGorry P, Pantelis C (1998) Neurological soft sings in prodromal patients. Schizophr Res 29:182–183. 43. Mittal VA, Dean DJ, Bernard JA, Orr JM, Pelletier-Baldelli A, Carol EE, Gupta T, Turner J, Leopold DR, Robustelli BL (2014). 44. Barkus E, Stirling J, Hopkins R, Lewis S (2006). The presence of neurological soft signs along the psychosis proneness continuum. Schizophr Bull 32:573–577. 45. Woods BT, Kinney DK, Yurgelun‐Todd DA. Neurological “hard” signs and family history of psychosis in schizophrenia. Biol Psychiatry 1991;30:806‐16. 46. Varambally S, Venkatasubramanian G, Gangadhar BN. Neurological soft signs in schizophrenia – The past, the present and the future. Indian J Psychiatry 2012;54:73‐80. 47. Chan R, Cui H, Chu M, Zhang T, Wang T, Li Z, et al. Neurological soft signs precede the onset of schizophrenia: a study of individuals with schizotypy, ultra-high-risk individuals, and first-onset schizophrenia Eur Arch Psychiatry Clin Neurosci 2017 DOI 10.1007/s00406-017-0828-4. 48. Manschreck TC, Ames D: Neurologic features and psychopathology. Biol Psychiatry 1984; 19:703-719. 49. Bora E et al. Neurological soft signs in bipolar disorder in comparison to healthy controls and schizophrenia: A meta-analysis, European Neuropsychopharmacology (2018), https://doi.org/10.1016/j.euroneuro.2018.08.006. 50. Dazzan P, Murray RM. Neurological soft signs in first episode psychosis: a systematic review. Br J Psychiatry. 2002;181(suppl 43):50–57. 51. Peralta V, de Jalón EG, Campos MS, Basterra V, Sanchez-Torres A , Cuesta MJ. Risk factors, pre-morbid functioning and episode correlates of neurological soft signs in drug-naive patients with schizophrenia-spectrum disorders. Psychol Med. 2011 Jun;41(6):1279-89. 52. King DJ, Wilson A, Cooper SJ, Waddington JL. The clinical correlates of neurological soft signs in chronic schizophrenia. Br J Psychiatry 1991; 158:770-775 18. 53. Youssef HA, Waddington JL. Primitive (developmental) reflexes and diffuse cerebral dysfunction in schizophrenia and bipolar affective disorder: overrepresentation in patients with tardive dyskinesia. Biol Psychiatry 1988; 23:791-796. Declaración de conflictos de intereses: los autores no declaran conflictos de intereses. EDITORIAL SCIENS // 5

Biblioteca

Av. García del Río 2585 Piso 12 A - C.A.B.A
+54 11 2092 1646 | info@sciens.com.ar

Editorial Sciens, Todos los Derechos Reservados 2015