farmacología cardiovascular 29 | Marzode2015 En la actualidad, la vitamina D no puede ser considerada una droga antihipertensiva, pero es probable que juegue un rol fundamental como hormona reguladora en el aparato cardiovascular. El conocimiento del estatus de la misma en sangre y el uso de suplementos para normalizar bajos niveles podrían tener una enorme importancia en la evolución de hipertensión arterial y la enfermedad cardiovascular (1, 8, 34, 35). Referencias bibliográficas 1. Ferder L. Vitamina D, una nueva hormona antihipertensiva? Rev Fed Arg Cardiol 2013;42: 15-19 2. Dusso A. El sistema hormonal de la vitamina D: lo que sabemos y lo que queda por saber. Nefrologia 2011; 2:37-43. 3. De Lorenzo A, Salanova L, Bomback A. et al. Oral paricalcitol as antiproteinuric agent in chronic kidney disease. Nefrologia 2013;33: 709-15. 4. Duplancic D, Cesarik M, Kolja Poljak N et al. 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Hypertension 2010 55:1283-8. 25. Thadhani R, Appelbaum E, Pritchett Y .Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial. JAMA 2012;307:674-8. 26. Dabelea D, Kinney G, Snell-bergeon JK et al. Coronary artery calcification in Type 1 Diabetes Study. Effect of Type 1 Diabetes on the gender difference in coronary artery calcification: a role for insulin resistance? The Coronary Artery Calcification in Type 1 diabetes (CACTI) Study. Diabetes 2003;52:2833-9. 27. Young K, Snell-Bergeon J, Ramachandra G et al. Vitamin D deficiency and coronary artery calcification in subjects with Type 1 Diabetes. Diabetes Care 2011;34:454-458. 28. Joergensen C, Hovind P, Schmedes A et al. Vitamin D levels, microvascular complications, and mortality in Type 1 Diabetes. Diabetes Care 2011;34:1081-5. 29. Joergensen C , Gall MA , Schmedes A et al. Vitamin D levels and mortality in Type 2 Diabetes. Diabetes Care 2010: 33;2238-43. 30. Giovannucci E, Liu Y et al. 25-hydrxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med 2008;168:1174-80. 31. Krause R, Buhring M et al. Ultraviolet B and blood pressure. Lancet 1998;352: 709-10. 32. Sugden JA, Davies JL et al. Vitamin D improves endotelial function in patients with Type 2 diabetes mellitus and low vitamin levels. Diab Med 2008; 25:320-25. 33. Vimaleswaran K et al. Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomization study. Lancet 2014;2:719-29. 34. González Parra E, Rojas-Rivera J et al. Vitamin D receptor activation and cardiovascular disease. Nephrology Dialysis Transplantation 2012; 27: 17-21. 35. Tamez H et al. Does vitamin D modulate blood pressure? Curr Opin Nephrol Hypertens 2013; 22:204-09. Editorial Sciens | 19
