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38 - I Recabarren - Junio 2017

  • Text
  • Cardiaca
  • Recabarren
  • Gmpc
  • Utilidad
  • Pacientes
  • Angina
  • Cardiaca
  • Efectos
  • Tolerancia
  • Desarrollo
  • Efecto
  • Nitratos
Mecanismos biológicos y farmacológicos de la utilización de nitratos

esponse. Circulation.

esponse. Circulation. 1981;64:1089–97. • Cocco G, Jerie P and Hans-Ulrich I Use of nitrates in ischemic heart disease, Expert Opinion on Pharmacotherapy, 2015;16: 1567- 1572. • Münzel T, Daiber A, Gori T. Nitrate therapy: new aspects concerning molecular action and tolerance. Circulation 2011;123:2132-44. • Toda N, Ayajiki A, and Okamura T Interaction of Endothelial Nitric Oxide and Angiotensin in the Circulation. Pharmacol Rev2007; 59:54–87. • Steinhorn B, Loscalzo J, and Michel T Nitroglycerin and Nitric Oxide — A Rondo of Themes in Cardiovascular Therapeutics, N Engl J Med 2015; 373:277-280. • Chouchani ET, Methner C, Nadtochiy SM, et al. Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med 2013;19:753-759. • Fernhoff NB, Derbyshire ER, Marletta MA. A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase. Proc Natl Acad Sci U S A. 200;106:21602–7. • Wenzl MV, Beretta M, Griesberger M, et al Site-directed mutagenesis of aldehyde dehydrogenase-2 suggests three distinct pathways of nitroglycerin biotransformation. Mol Pharmacol 2011;80:258–266. • Parker JD and Gori T,Tolerance to the Organic Nitrates; New Ideas, New Mechanisms, Continued Mystery, Circulation. 2001;104: 2263-2265. • Toda N and Okamura T The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels, Pharmacological Reviews 2003;55:271-324. • Mulsch A, Oelze M, Kloss S, et al. Effects of in vivo nitroglycerin treatment on activity and expression of the guanylyl cyclase and cGMPdependent protein kinase and their downstream target vasodilator-stimulated phosphoprotein in aorta. Circulation. 2001; 103: 2188–2194. • Thomas GR, DiFabio JM, Gori T, et al. Once Daily Therapy With Isosorbide-5-Mononitrate Causes Endothelial Dysfunction in Humans Evidence of a Free-Radical–Mediated Mechanism JACC 2007;49:1289–95. • Ural D, Kandemir AS, Karaüzüm K et al Effect of Oral Nitrates on All-Cause Mortality and Hospitalization in Heart Failure Patients with Reduced Ejection Fraction: A Propensity- Matched Analysis. Journal of Cardiac Failure 2017;23:4, 286-292. • Arstall MA, Yang J, Stafford I, et al. N-acetylcysteine in combination with nitroglycerin and streptokinase for the treatment of evolving acute myocardial infarction. Safety and biochemical effects. Circulation. 1995 92:2855–62. • Fraccarollo D, Galuppo P,Neuser J et al Pentaerythritol Tetranitrate Targeting Myocardial Reactive Oxygen Species Production Improves Left Ventricular Remodeling and Function in Rats With Ischemic Heart Failure Hypertension. 2015;66:978-987. • Taylor AL, Ziesche S, Yancy C, et al African- American Heart Failure Trial Investigators. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med.2004;351:2049–2057. • Gheorghiade M, Marti CN, Sabbah HN, et al. Academic Research Team in Heart Failure. Soluble guanylate cyclase: a potential therapeutic target for heart failure. Heart Fail Rev 2013;18:123–134. • Eryonucu B, Güler N, Güntekin U, et al Comparison of the Effects of Nitroglycerin and Nitroprusside on Transmitral Doppler Flow Parameters in Patients with Hypertensive Urgency Ann Pharmacother 2005;39:997- 1001. • Watanabe H, Kakihana M, Ohtsuka S et al Preventive effects of carvedilol on nitrate tolerance—a randomized, double-blind, placebocontrolled comparative study between carvedilol and arotinolol J Am Coll Cardiol Volume 32, Issue 5, 1 November 1998, Pages 1201–1206. • Thadani U and Wittig T A Randomized, Double-Blind, Placebo-Controlled, Crossover, Dose-Ranging Multicenter Study to Determine the Effect of Sublingual Nitroglycerin Spray on Exercise Capacity in Patients with Chronic Stable Angina;; Clinical Medicine Insights: Cardiology 2012:6 87-95. • Thomas Münzel et al Efficacy of the long-acting nitro vasodilator pentaerithrityl tetranitrate in patients with chronic stable angina pectoris receiving anti-anginal background therapywith beta-blockers: a 12-week, randomized, doubleblind, placebo-controlled trial; European Heart Journal (2014) 35, 895–903. • M. Ahmadinejad et al Slow-release isosorbide- 5-mononitrate—a new once daily therapeutic modality for angina pectoris, Eur Heart J (1988) 9 (suppl_A): 135-139. • Gao X, Yang T, Liu M, et al NADPH Oxidase in the Renal Microvasculature Is a Primary Target for Blood Pressure–Lowering Effects by Inorganic Nitrate and Nitrite; Hypertension. 2015;65:161-170. • Stokes GS, Bune AJ, Huon N, Barin ES. Long term effectiveness of extended-release for the treatment of systolic hypertension. Hypertension. 2005; 45: 380–384 14 | Editorial Sciens

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