Protocolos de estrés prenatal y de separación materna (MS) en roedores presentaron alteraciones en el sistema nervioso
central (SNC), por ejemplo, problemas de aprendizaje, consumo voluntario de alcohol, cambios neuroquímicos, etcétera. Se
cree que las propiedades de estos procedimientos tempranos en la vida están mediadas por la alta plasticidad del SNC en el
desarrollo. Durante la etapa crítica del desarrollo, las regiones del cerebro, principalmente aquellas relacionadas con condiciones agresivas, pueden tener anomalías de crecimiento a veces irreversibles y, por lo tanto, ajustar el procesamiento emocional
cuando se vuelven adultos. El período postnatal temprano y la relación entre la madre y el bebé son esenciales para la respuesta
normal al estrés, las emociones y el comportamiento. Probablemente, implique la activación de vías de señalización intracelular, adaptaciones del genoma, ajustes en la expresión génica y la acción neuronal. Las experiencias traumáticas en los primeros
años de vida son factores de riesgo para el desarrollo de trastornos emocionales y de conducta. Estos trastornos pueden persistir
hasta la edad adulta y a menudo, se ha informado que se transmiten de generación en generación. Estos hallazgos resaltan el
impacto negativo del estrés temprano en las respuestas conductuales entre generaciones y en la regulación de la metilación del
ADN en la línea germinal.
Psicofarmacología
Psicofarmacología 24:136, --- de 2024 Heim. Effects of stress throughout the lifespan on the brain, behaviour and cognition, Nature Reviews Neuroscience 10(6) (2009)434-445. • 7. M.H. Teicher, J.A. Samson, C.M. Anderson, K. Ohashi. The effects of childhood maltreatment on brain structure, function and connectivity, Nat. Rev. Neurosci. 17 (2016) 652–666. • 8. M. P. Herzberg, M.R. Gunnar. Early life stress and brain function: activity and connectivity associated with processing emotion and reward, Neuroimage 209 (2020) 116493. • 9. A.E. Takesian, T.K. Hensch. Balancing plasticity/ stability across brain development. Prog. Brain Res. 207 (2013) 3–34. • 10. B. Schmalbach, E. Lepsveridze, N. Djogo, G. Papashvili, F. Kuang, I. Leshchynska, V. Sytnk, A.G. Nikonemko, A. Dityatev, I Jakovceyski, M Schachner. Age-dependent loss of parvalbumin-expressing hippocampal interneurons in mice deficient in CHL1, a mental retardation and schizophrenia susceptibility gene. J. Neurochem. 135 (2015) 830–844. • 11. A. Dubravka, J. Poleksic, G. Agatonovic, V. Djulejic, M. Vulovic, M. Aksic, G. Reiss, M. I. K. Hamad, I. Jakovcevski, M. Aksic. The long-term effects of maternal deprivation on the number and size of inhibitory interneurons in the rat amygdala and nucleus accumbens, Front Neurosci 26 (2023) 17:1187758. • 12. Y. Ben-Ari, I. Khalilov, A. Represa, H. Gozlan. Interneurons set the tune of developing networks, Trends Neurosci. 27 (2004) 422–427. • [13] S.L. Marguet, V.T. Le-Schulte, A. Merseburg, E. Neu, I. Jakovcevski, A. Ivanov, I.L. Hanganu-Opatz, C. Bernard, F. Morellini, D. Isbrandt. Treatment during a vulnerable developmental period rescues a genetic epilepsy. Nat. Med. 21 (2015), 1436–1444. • 14. D. Hogan, N.E. Berman. Transient expression of calbindin-D28k immunoreactivity in layer V pyramidal neurons during postnatal development of kitten cortical areas, Brain Res. Dev. Brain Res. 74 (1993) 177–192. • 15. N. Hajos. Interneuron types and their circuits in the basolateral amygdala. Front. Neural Circuits 15 (2021) 687257. • 16. D. Aleksi, M. Aksi, N.V. Radonji, A. Jovanovi, B. Markovi, N. Petronijevi, V. Radonjic, M Mails, B. Filipovic. Long-term effects of maternal deprivation on the volume, number and size of neurons in the amygdala and nucleus accumbens of rats, Psychiatr. Danub. 28 (2016) 211–219. • 17. W.E. Copeland, L. Shanahan, J. Hinesley, R.F. Chan, K.A. Aberg, J.A. Fairbank, E.J.C. G. van den Oord, E. Jane Costello. Association of childhood trauma exposure with adult psychiatric disorders and functional outcomes. JAMA Netw. Open 1 (7) (2018) 1:e184493. • 18. H.M. Appelmann, A.W. Manigault, R. C. Shorey, P.M. Zoccola. Childhood adversity and cortisol habituation to repeated stress in adulthood. Psychoneuroendocrinology 125 (2021)105118. • 19. D. Marchetti, P. Musso, M.C. Verrocchio, G. Manna, D.C. Kopala-Sibley, D. De Berardis, S. De Santis, G. Falgares. Childhood maltreatment, personality vulnerability profiles, and borderline personality disorder symptoms in adolescents. Dev. Psychopathol. 26 (2021) 1–14. • 20. J.D. Bremner, P. Randall, E. Vermetten, L. Staib, R.A. Bronen, C. Mazure, S. Capelli, G. Mc- Carthy, R.B. Innis, D.S. Charney. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse–a preliminary report. Biol. Psychiatry 41 (1997) 23–32. • 21. G.C. Medeiros, W. L. Prueitt, A. Minhajuddin, S.S. Patel, A.H. Czysz, J.L. Furman, B.L. Mason, A.J. Rush, M.K. Jha, M.H. Trivedi. Childhood maltreatment and impact on clinical features of major depression in adults. Psychiatry Res. 293 (2020)113412. • 22. A.R. King. Childhood adversity links to self-reported mood, anxiety, and stress-related disorders. J. Affect. Disord. 292 (2021) 623–632. • 23. L.A. Quagliato, D. A. Coelho, U.M.A. de Matos, A.E. Nardi. Physical abuse during childhood predicts IL-2R levels in adult panic disorder patients. J. Affect Disord. 295 (2021) 1440–1444. doi: 10.1016/j.jad.2021.09.022. • 24. M. C. Fenton, T. Geier, K. Keyes, A.E. Skodol, B.F. Grant, D.S. Hasin. Combined role of childhood maltreatment, family history, and gender in the risk for alcohol dependence. Psychol. Med. 43 (2013) 1045–1057. • 25. E. McCrory, S.A. De Brito, E. Viding. The link between child abuse and psychopathology: A review of neurobiological and genetic research. J. R. Soc. Med. 105 (2012) 151–156. • 26. P-E. Lutz, M.A. Chay, A. Pacis, G.G. Chen, Z. Aouabed, E. Maffioletti, J.F. Théroux, J.C. Grenier, J Yang, Aguirre, C. Ernst, A. Redensk. L. C. van Kempem, I Yalcin, T. Kwan, N. Mechawae, T. Pastinen, G. Turecki (2021). Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation. Nat. Commun. 12 (2021) 1132. • 27. L. Lim, H. Hart, M. Mehta, A. Worker, A. Simmons, K. Mirza, K. Rubia. Grey matter volume and thickness abnormalities in young people with a history of childhood abuse. Psychol. Med. 48 (2018) 1034–1046. • 28. C. Raineki, M.R. Cortés, L. Belnoue, R.M. Sullivan. Effects of early-life abuse differ across development: infant social behavior deficits are followed by adolescent depressive-like behaviors mediated by the amygdala. J. Neurosci. 32 (2012) 7758–7765. • 29. M. Aksi, N.V. Radonji, D. Aleksi, G. Jevti, B. Markovi, N. Petronijevi, V. Radonji´c, B. Filipovi´c. Long-term effects of maternal deprivation on the neuronal soma area in the rat neocortex. Biomed. Res. Int. (2014) 235238. • 30. M. Aksi, J. Poleksic, D. Aleksic, N. Petronijevic, N.V. Radonjic, M. Jakovcevski, S. Kapor, N. Divac, B.R. Filipovic, I. Jakovcevski. Maternal deprivation in rats decreases the expression of interneuron markers in the neocortex and Hippocampus. Front. Neuroanat. 15 (2021) 670766. • 31. D. Aleksi, M. Aksi, N.V. Radonji, A. Jovanovi, B. Markovi, N. Petronijevi, V. Radonjic, B. Filipovic. Long-term effects of maternal deprivation on the volume, number and size of neurons in the amygdala and nucleus accumbens of rats. Psychiatr. Danub. 28 (2016) 211–219. • 32. E. Ryakiotakis, D. Fousfouka, A. Stamatakis. Maternal neglect alters reward-anticipatory behavior, social status stability, and reward circuit activation in adult male rats, Front Neurosci (2023)17:1201345. • 33. Y. Takatsuru, M. Yoshitomo, T. Nemoto, K. Eto, J. Nabekura. Maternal separation decreases the stability of mushroom spines in adult mice somatosensory cortex. Brain Res. 1294 (2009) 45–51. • 34. S. Toya, Y. Takatsuru, M. Kokubo, I. Amano, N. Shimokawa, N. Koibuchi. Early-life-stress affects the homeostasis of glutamatergic synapses. Eur. J. Neurosci. 40 (2014) 3627–3634. • 35. K. Miyagawa, M. Tsuji, K. Fujimori, Y. Saito, H. Takeda. Prenatal stress induces anxiety-like behavior together with the disruption of central serotonin neurons in mice. Neurosci. Res. 70 (2011) 111–117. • 36. K. Miyagawa, M. Tsuji, D. Ishii, K. Takeda, H. Takeda. Prenatal stress induces vulnerability to stress together with the disruption of central serotonin neurons in mice. Behav. Brain Res. 277 (2015) 228–236. • 37. P. Pervanidou, G.P. Chrousos. Early-life stress: from neuroendocrine mechanisms to stress-related disorders. Horm. Res. Paediatr. 89 (2018) 372–379. • 38. M.F. Juruena, F. Eror A.J. Cleare, A.H. Young. The role of early life stress in HPA axis and anxiety. Adv. Exp. Med. Biol. 1191 (2020) 141–153. • 39. J. LeMoult, K.L. Humphreys, A. Tracy, J.A. Hoffmeister, E. Ip, I.H. Gotlib. Meta-analysis: exposure to early life stress and risk for depression in childhood and adolescence. J. Am. Acad. Child Adolesc. Psychiatry 59 (2020) 842–855. • 40. S. Bennett, A.J. Thomas. Depression and dementia: cause, consequence or coincidence? Maturitas 79 (2014) 184–190. • 41. S. Hayley, A.M. Hakim, P. R. Albert. Depression, dementia and immune dysregulation. Brain 144 (2021) 746–760. EDITORIAL SCIENS // 7
Gabriela B Acosta • 42. M.A. Harris, C.E. Brett, J.M. Starr, I.J. Deary, A.M. McIntosh. Early-life predictors of resilience and related outcomes up to 66 years later in the 6-day sample of the 1947 Scottish mental survey. Soc. Psychiatry Psychiatr. Epidemiol. 51 (2016) 659–668. • 43. P.H. Wise. Child poverty and the promise of human capacity: childhood as a foundation for healthy aging. Acad. Pediatr. 16 (3 Suppl.) (2016)7S37–S45. • 44. H. Yajima, A. Haijima, M.A. Khairinisa, N. Shimokawa, I. Amano, Y. Takatsuru. Early-life-stress induces cognitive disorder in middle-aged mice. Neurobiol. Ageing 64 (2018) 139–146. • 45. C. Heim, D.J. Newport, R. Bonsall, A.H. Miller, C. B. Nemeroff. Altered pituitary–adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. Am. J. Psychiatry 158 (2001) 575–581. • 46. C.S. Widom, S.J. Czaja, K.A. DuMont. Intergenerational transmission of child abuse and neglect: real or detection bias? Science 347 (2015) 1480–1485. • 47. S. Mitani, I. Amano, Y. Takatsuru. High prolactin concentration during lactation period induced disorders of maternal behavioral in offspring. Psychoneuroendocrinology 88 (2018) 129–136. • 48. A. Bifulco, P.M. Moran, C. Ball, C. Jacobs, R. Baines, A. Bunn, et al. Childhood adversity: parental vulnerability and disorder: examining intergenerational transmission of risk. J. Child. Psychol. Psychiatry 43 (2002) 1075–1086. • 49. H.K. Kim, D.M. Capaldi, K.C. Pears, D.C. Kerr, L.D. Owen, L. D. (2009). Intergenerational transmission of internalising and externalising behaviours across three generations: gender-specific pathways. Crim. Behav. Ment. Health 19 (2009) 125–141. • 50. C. Heim, M. Shugart, W.E. Craighead, C.B. Nemeroff, C. B. Neurobiological and psychiatric consequences of child abuse and neglect. Dev. Psychobiol. 52 (2010) 671–690. • 51. N.M. Cameron, D. Shahrokh, A. Del Corpo, S.K. Dhir, M. Szyf, F.A. Champagne, et al. Epigenetic programming of phenotypic variations in reproductive strategies in the rat through maternal care. J. Neuroendocrinol. 20 (2008) 795–801. • 52. T.B. Franklin, H. Russig, I.C. Weiss, J. Gräff, N. Linder, A. Michalon, S. Vizi, I.M. Mansuy. Epigenetic transmission of the impact of early stress across generations. Biol. Psychiatry 68 (2010) 408–415. • 53. C. Heim, E.B. Binder. Current research trends in early life stress and depression: review of human studies on sensitive periods gene-environment interactions, and epigenetics. Exp. Neurol. 233 (2011) 102–111. • 54. I.C. G. Weaver, N. Cervoni, F.A. Champagne, A.C. D’Alessio, S. Sharma, J.R. Seckl, S, Dymov, M. Szyf, M.J. Meanet. Epigenetic programming by maternal behavior. Nat. Neurosci. 7 (2004)847– 854. • 55. L. Gabard-Durnam, K.A. McLaughlin. Do sensitive periods exist for exposure to adversity? Biol Psychiatry. 85 (2019)789–91. • 56. M. Li, C. D’Arcy, X. Meng. Maltreatment in childhood substantially increases the risk of adult depression and anxiety in prospective cohort studies: systematic review, meta-analysis, and proportional attributable fractions. Psychol Med. 46 (2016):717–30. • 57. H. Kim, B. Drake. Cumulative prevalence of onset and recurrence of child maltreatment reports. J Am Acad Child Adolesc Psychiatry. 58 (2019)1175–83. 8 // EDITORIAL SCIENS
