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Gliflozinas en insuficiencia cardiaca con fracción de eyección reducidaDra. Agustina Piccinato, Dra. Silvina L Cacia, Dr. Ezequiel J Zaidel.

  • Text
  • Sciens
  • Piccinato
  • Cacia
  • Fracción eyección
  • Insuficiencia cardíaca
  • Diabetes
  • Glifozinas
  • Wwwscienscomar
  • Zaidel
  • Farmacologia
  • Sujetos
  • Gliflozinas
  • Fraction
  • Ejection
  • Dapagliflozin
  • Efectos
  • Reduced
  • Pacientes
  • Insuficiencia
  • Cardiovascular
Las gliflozinas habían demostrado ser fármacos útiles en sujetos con diabetes tipo 2 con una reducción de aproximadamente el 30% en la incidencia de insuficiencia cardiaca. Por ello, fueron evaluadas como terapéutica de la insuficiencia cardíaca. En este artículo se revisa la fisiopatología, mecanismo de acción y descripción de los resultados de los dos grandes ensayos clínicos pivotales: DAPA-HF y EMPEROR-Reduced., donde se comprobó la seguridad y eficacia de los inhibidores SGLT2 en la terapéutica, incorporándose como el cuarto pilar del tratamiento de los pacientes con IC crónica y fracción de eyección reducida.

farmacología

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