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N-acetilcisteína (NAC) y consumo de cocaína Dr. José Alberto Angemi

  • Text
  • Cocaina
  • Nac
  • Acetilcisteína
  • José angemi
  • Wwwscienscomar
  • Angemi
  • Nota
  • Estudio
  • Dependientes
  • Glutamato
  • Trastornos
  • Aumento
  • Cocaine
  • Ratas
  • Dosis
  • Efectos
  • Consumo
La N-Acetilcisteína es un derivado del aminoácido no esencial cisteína, precursor del antioxidante glutatión, a su vez modulador de las vías glutamatérgicas neurotróficas e inflamatorias. Su utilización en distintas entidades neuropsiquiátricas va en aumento. En este trabajo se realiza una revisión sobre la probable utilidad del fármaco en consumo problemático de cocaína. Para ello se realiza una búsqueda en las siguientes bases de datos: Pub Med, Lilacs, Google Académico, DOAJ, PsycINFO y Psiquiatría.com. Se utilizan las palabras clave mencionadas y sus combinaciones. A la espera de más estudios y de mejor calidad, los realizados a la fecha tanto en ratas como en humanos, in vivo e in vitro, resaltan varios aspectos interesantes. Se mostraron efectos beneficiosos para el craving, los trastornos cognitivos, la toxicidad hepática, cardiológica, pulmonar, endotelial y SNC, con un perfil de efectos adversos muy favorable.

Psicofarmacología

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